A cluster of hantavirus cases struck the Dutch-flagged cruise ship MV Hondius as it traveled across the southern Atlantic, stopping at a number of destinations along the way.
Public health authorities' investigations are ongoing. Gaps in knowledge are expected during an unfolding investigation, and as those gaps are filled, we will update you here.
Here's everything you need to know:
- The cluster of hantavirus cases began on the Dutch-flagged MV Hondius cruise ship, which set off from southern Argentina on April 1 carrying some 150 people, including 17 from the United States.
- So far, there have been five confirmed cases of hantavirus linked to the outbreak, according to the World Health Organization (WHO).
- Three people have died after being on board the ship during the outbreak, although not all the deaths have been confirmed to have been infected with hantavirus. At least five people linked to the outbreak are receiving medical treatment in hospitals.
- The ship stopped at a number of destinations along the way. A total of roughly 40 people disembarked from the ship at St. Helena after the first passenger death, including about seven American citizens who are now spread across several states. The WHO and U.S. Centers for Disease Control and Prevention (CDC) are coordinating to assess those individuals.
- Laboratory tests point to the Andes virus as the type of hantavirus implicated — the only hantavirus known to pass from human to human.
- It's relatively uncommon for hantaviruses to cause infections in humans, and when they do, people usually catch them from rodents. In this case, health authorities suspect some person-to-person spread may be at play.
- The U.S. CDC and WHO emphasize that the risk to the public remains low.
This blog is for informational purposes only and is not meant to offer medical advice. We endeavor to keep the information in this live feed timely and accurate, so parts of this page may be updated or corrected as new details emerge.
Viral videos of distressed passengers
When asked about videos of some cruise passengers expressing distress that are circulating online, Maria Van Kerkhove, the WHO's interim director of epidemic and pandemic preparedness and prevention, confirmed that WHO officials had seen them.
"This is quite frightening for those that are on board," she added, noting that health authorities are coordinating with the ship's captain to ensure those on the ship receive the best medical and psychological care possible.
Additionally, once the medical status of everyone on board is assessed, the WHO will also coordinate with each person's home country to safely repatriate them.
Deceased passenger remains on board
The body of the third person to die in the outbreak — a woman who passed away on board on May 2 after developing pneumonia — is still being stored on the MV Hondius. WHO officials are in contact with the cruise operators about safe storage and eventual transport of the remains.
Genetic sequencing underway
Genetic material from the confirmed hantavirus cases is now being sequenced. This will enable experts to compare the genetics of the hantaviruses involved in this cluster to those that caused past outbreaks.
As of yet, there's "no indication" that there's anything particularly unusual about the hantaviruses themselves, but it is notable that the outbreak is taking place on a cruise ship, said Anaïs Legand, the WHO's technical officer of viral hemorrhagic fevers. A ship is a unique environment where people from many places are in close quarters.
Monitoring of potential contacts
People who have potentially been exposed to the virus are being "actively monitored," according to Dr. Abdirahman Mahamud, Director of the WHO's Health Emergency Alert and Response Operations. What that looks like depends on the country where the case contacts are currently located; some may be quarantined in facilities while others receive a daily visit from health care workers, for instance, he said.
The WHO recommends that contacts be monitored for six weeks, as the incubation period of hantavirus infections can be that long. Known cases that are symptomatic are being isolated and cared for in hospitals.

Where did the infection come from?
WHO Director-General Tedros Adhanom Ghebreyesus told reporters at the news conference that the WHO is working with health authorities in Argentina to investigate where the first two cases on board the ship got infected. Those passengers, a husband and wife, marked the first two deaths associated with the outbreak.
Prior to boarding, "the first two cases traveled through Argentina, Chile and Uruguay, on a birdwatching trip, which included visits to sites where the species of rat known to carry Andes virus was present," Ghebreyesus said.
The Andes virus is transmitted to humans mainly through contact with the long-tailed pygmy rice rat (Oligoryzomys longicaudatus). People may pick up the virus through exposure to the rat's urine, feces or saliva. For instance, they may accidentally touch the rat's feces and then touch their face, or alternatively, breathe in viral particles that get released into the air when rodent droppings get disturbed in the environment.

"Viruses don't care about politics"
Both Argentina and the U.S. recently withdrew from the World Health Organization (WHO). In the face of this outbreak, "I think they will reconsider their positions," said Tedros Adhanom Ghebreyesus, the WHO's director-general. "Viruses don't care about our politics; they don't care about our borders, and they don't care about all the excuses that we may have."
When asked whether U.S. health authorities are participating in the ongoing investigation, several WHO representatives confirmed that the U.S. Centers for Disease Control and Prevention is providing helpful technical support and expertise and communicating with WHO leaders daily.

World Health Organization says risk to the public is "low"
Maria Van Kerkhove at a WHO news conference.
The World Health Organization (WHO) just held a news conference to discuss the hantavirus cases.
The WHO has been working with collaborating centers to identify the type of the virus behind the outbreak, as well as investigate suspected and confirmed cases and perform contact tracing. The agency has also been quick to quash fears that the outbreak could spark a global pandemic.
"This is not SARS-CoV-2 [the virus that causes COVID-19]. This is not the start of a COVID pandemic. This is an outbreak that we see on a ship," Maria Van Kerkhove, the WHO's interim director of epidemic and pandemic preparedness and prevention, said at the news conference.
"This is not the same situation we were in six years ago," she continued. "It [the Andes virus] doesn't spread the same way like coronaviruses do. It's very different. It's that close, intimate contact that we've seen, and most hantaviruses don't transmit between people at all."
"The Andes virus, which has been identified here, we've seen some human-to-human transmission," she added. "I want to reiterate [that] the actions that are being taken on board are precautionary to prevent any onward spread, and so there's a lot that is being done right now to be able to try to minimize the risk even further."
What is hantavirus, and how risky is this outbreak?
Hantaviruses are a family of viruses carried by rodents. Hantavirus infections in humans are relatively uncommon, but when they do occur, they can be dangerous, with fatality rates ranging between 1% up to 50% depending on the type of virus at hand. No specific treatment exists to cure infections, but prompt medical care can improve patients' chances of survival.
While most hantaviruses cannot pass between people, one specific type, known as the Andes virus, can. The Andes virus is the type of hantavirus that laboratory tests point to being behind this cluster. Health authorities are now working to analyze the virus's DNA in order to compare its sequence to that of Andes viruses involved in past outbreaks.
The World Health Organization and the U.S. Centers for Disease Control and Prevention have both said that the risk posed to the public from this cluster remains low, although they continue to monitor the situation.
For more on the Andes virus, you can read health editor Nicoletta's story here. And for more background information on hantaviruses, broadly, you can read this story.

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