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In Images: A 'Google Maps' for the Mouse Brain

Tiny slices

allen mouse common coordinate framework

(Image credit: Allen Institute for Brain Science)

Researchers recently created a type of Google Maps for the mouse brain. The project, called the Allen Mouse Common Coordinate Framework, began with 234,500 individual sections from 1,675 whole mouse brains. These were collected as part of the Allen Mouse Brain Connectivity Atlas.

An average brain

mouse brain

(Image credit: Allen Institute for Brain Science)

A computer program then averaged all 1,675 specimens into a single 3D image, which then became the archetypal average mouse brain for the project.

Not your average mouse

brain of a mouse

(Image credit: Allen Institute for Brain Science)

Here, one view of this average mouse brain. After the brain was averaged, other sophisticated algorithms were used to clean up noise in messy images and improve the spatial resolution.

Glowing brain cells

brain of a mouse

(Image credit: Allen Institute for Brain Science)

Next, anatomists painstakingly tracked fluorescently labeled neurons to identify boundaries between brain regions.

An average brain

mouse brain

(Image credit: Allen Institute for Brain Science)

The team then created an antomical model that revealed the boundary regions in the mouse brain, shown here in different colors.

Detailed brain regions

mouse brain

(Image credit: Allen Institute for Brain Science)

Another view of the boundaries between brain regions in a mouse, as defined by data from the Allen Brain Atlas Mouse Connectivity project.

Anatomical structure

mouse brain

(Image credit: Allen Institute for Brain Science)

Here, more views of these individual brain regions.

Top view of the mouse brain

mouse brain

(Image credit: Allen Institute for Brain Science)

Though the project is focused on mapping connections in a mouse brain in 3D, the ultimate goal is to do the same for the human brain. here, the same boundaries in the mouse brain shown in a different view.

Capturing connections

mouse brain

(Image credit: Allen Institute for Brain Science)

As part of the Allen Institute’s ongoing Cell Types Database project, scientists take high-resolution pictures of individual neurons

Digitally encoded neurons

mouse brain

(Image credit: Allen Institute for Brain Science)

From high resolution images of individual neurons, the researchers created digital reconstructions of those cells The green portion shows the dendrite, while the pink shows the apical dendrite. The gray shows the axon.

A view of the brain

mouse brain

(Image credit: Allen Institute for Brain Science)

Here, another view of the Allen Common Connectivity Framework, which acts as a Google Maps or GPS for the brain