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The first (A) and fourth (B) day after seeding the mesh frame, the researchers found the skin cells spread from the corners into the meshes, reaching one another within a week.
The secret to creating artificial skin might be spider silk, researchers now suggest.
Skin grafts are vital for treating burn victims and other patients. For instance, chronic wounds such as bedsores in hospitalized patients afflict 6.5 million in the United States alone for estimated costs of $25 billion annually.
Instead of using skin from a body for a graft, scientists are investigating artificial skin. Ideally such a graft would be of a material tolerated by the body, have skin cells embedded within it to replace lost tissue, degrade safely over time as the new skin grows in and be strong enough to withstand all the rigors ordinary skin experiences. Materials investigated until now did not seem strong enough for the task, said tissue engineer Hanna Wendt at Medical School Hannover in Germany.
The extraordinary strength and stretchiness of spider silk "are important factors for easy handling and transfer of many kinds of implants," Wendt said. In addition, unlike silk from silkworms, that from spiders apparently does not trigger the body's rejection reactions.
On the spider-silk meshes, the team cultivated the skin cells into "tissues" resembling epidermis, the skin's outermost layer.
(Image credit: Hanna Wendt et al., PLoS ONE)
To test spider silk's usefulness, first Wendt and her colleagues essentially milked golden silk orb-weaver spiders by stroking their silk glands and spooling up the silk fibers that came out. They next wove meshes from this silk onto steel frames. [See images of skin cells growing]
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The researchers found that human skin cells placed on these meshes could flourish, given proper nurturing with nutrients, warmth and air. They were able to cultivate the two main skin cell types, keratinocytes and fibroblasts, into tissue-like patterns resembling epidermis, the outermost layer of skin, and dermis, the layer of living tissue below the epidermis that contains blood capillaries, nerve endings, sweat glands, hair follicles and other structures.
"It was impressive to observe how human cells use spider silk," Wendt told LiveScience.
Currently, harvesting large amounts of spider silk for industrial standards is not practical. "I think in the long term, for widespread daily clinical use, synthetic silk fibers providing the same mechanical- and cell culture- properties will be needed," Wendt said. Currently, many research groups are investigating ways to grow synthetic spider silk.
The scientists detailed their findings online July 26 in the journal PLoS ONE.
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Charles Q. Choi is a contributing writer for Live Science and Space.com. He covers all things human origins and astronomy as well as physics, animals and general science topics. Charles has a Master of Arts degree from the University of Missouri-Columbia, School of Journalism and a Bachelor of Arts degree from the University of South Florida. Charles has visited every continent on Earth, drinking rancid yak butter tea in Lhasa, snorkeling with sea lions in the Galapagos and even climbing an iceberg in Antarctica.
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