Lithium Medication: Dosage & Side Effects

Three forms of lithium medications. Top left: Lithobid brand extended-release tablet. Bottom left: generic oral tablet. Right: generic capsule.
Credit: NIH.

Lithium is used in medications prescribed for people with bipolar disorder, a mental illness that causes episodes of depression, mania and other abnormal moods. Lithium medications are used to treat and possibly prevent episodes of mania, which is described as a “frenzied, abnormally excited mood,” according to the National Institutes of Health.

Lithium, in a class of drugs called antimanic agents, works by decreasing abnormal activity in the brain. Doctors hypothesize that it strengthens the brain’s nerve cell connections that regulate mood, thinking and behavior, according to the NIH.

Lithium medications are often prescribed as a long-term treatment, not to be stopped when the patient feels better. They are also sometimes prescribed for blood disorders, depression, schizophrenia, impulse control disorders and certain mental illnesses in children.

Lithium carbonate & other compounds

Various compounds of lithium, the third element on the Periodic Table of Elements, are used in the medications. The most commonly prescribed is lithium carbonate, which is sold under various brand names, including Eskalith CR and Lithobid. Lithium citrate is also prescribed as a mood stabilizer. The soft drink 7Up was originally called "Bib-Label Lithiated Lemon-Lime Soda" because it contained lithium citrate.

Lithium orotate is a dietary supplement touted as a natural treatment for mental health problems. It is sometimes promoted as an alternative to lithium and its side effects. However, lithium orotate has not been approved by the Food and Drug Administration for the treatment of any medical condition.


The prescribed dose of lithium medications varies from person to person and from phase to phase of illness. Doctors may increase or decrease the dose of medication during treatment, and is important to follow the most current directions. Furthermore, bipolar disorder is sometimes treated with more than one drug, so lithium dosage can depend on the presence of other drugs.

Lithium medications are available as tablets, capsules, extended-release tablets, and liquids taken by mouth. All but the extended-release tablet are usually taken three to four times a day. Extended-release tablets are usually taken two to three times per day. They should not be split, chewed or crushed; extended-release tablets should be swallowed whole. Medications should be taken around the same time every day.

Lithium medications can help control bipolar symptoms but will not cure the disorder. It usually takes several weeks for the medications to begin working, and it is important to continue to take them even if the symptoms cease. Lithium works best if it is kept at a constant level in your body, so doctors may suggest drinking eight to twelve glasses of water per day and maintaining a consistent amount of salt in your food. Both fluid and salt can affect the levels of lithium in the blood, so it is important to consume a consistent amount every day.

Side effects

Lithium medications may cause side effects. Doctors typically want patients to take regular blood tests during lithium use because it can affect kidney or thyroid functioning.

The NIH recommends telling a doctor if any of the following side effects become severe or do not go away:

  • restlessness
  • fine hand movements that are difficult to control
  • loss of appetite
  • stomach pain or bloating
  • gas
  • indigestion
  • weight gain or loss
  • dry mouth
  • excessive saliva in the mouth
  • tongue pain
  • change in the ability to taste food
  • swollen lips
  • acne
  • hair loss
  • unusual discomfort in cold temperatures
  • constipation
  • depression
  • joint or muscle pain
  • thin, brittle fingernails or hair

The following side effects are serious and, if they appear, a doctor should be consulted immediately:

  • tiredness
  • shaking of a part of your body that you cannot control
  • muscle weakness, stiffness, twitching, or tightness
  • loss of coordination
  • diarrhea
  • vomiting
  • excessive thirst
  • frequent urination
  • giddiness
  • ringing in the ears
  • slow, jerky movements
  • movements that are unusual or difficult to control
  • blackouts
  • seizures
  • slurred speech
  • fast, slow, irregular, or pounding heartbeat
  • chest tightness
  • confusion
  • hallucinations (seeing things or hearing voices that do not exist)
  • crossed eyes
  • painful, cold, or discolored fingers and toes
  • headache
  • pounding noises inside the head
  • changes in vision
  • paleness
  • itching
  • rash
  • swelling of the eyes, face, lips, tongue, throat, hands, feet, ankles, or lower legs

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