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Bad Medicine

Oops! 5 Retracted Science Studies

Bad science?

frozen test tube

Every year hundreds of science papers are retracted, most involving no blatant malfeasance, but others are due to cooked data. And 2012 was no different.
(Image credit: Dreamstime)

When you read about medical breakthroughs in the newspapers, you shouldn't get your hopes up. This is not because of journalistic hyperbole or even the fact that cures often are years away from the initial publication of result.

It seems that an increasing number of scientific studies are just plain wrong and are ultimately retracted. Worse, a study published in October 2012 in the Proceedings of the National Academy of Sciences (uh, if it's true) claims that the majority of retractions are due to some type of misconduct, and not honest mistakes, as long assumed. Here are 5 doozies from 2012

Hyung-In Moon is a genius, says Moon

a 3-D fractal illustration

Erik Andrulis of Case Western suggest everything around us oscillates between excited and ground states as objects pivot around the center of these lifelike gyres, or spinning spirals.
(Image credit: R.T. Wohlstadter | Shutterstock)

Korean scientist Hyung-In Moon took the concept of scientific peer review to a whole new level by reviewing his own papers under various fake names. Not surprising, his imaginary peers were quite impressed with his work.

But perhaps also not surprising from someone who attempts such a scheme, Moon's research — which included a study on alcoholic liver disease and another on an anticancer plant substance — can't be trusted. Moon admitted to falsifying data in some of his papers, according to Chronicle of Higher Education. So far, 35 of his papers have been retracted in 2012.

Math paper a big, fat zero

Equations on a chalkboard

Equations aren't just useful' they're often beautiful.
(Image credit: Shutterstock/Fedorov Oleksiy)

Neither the one-sentence abstract — "In this study, a computer application was used to solve a mathematical problem" — nor the co-author's e-mail address, ohm@budweiser.com, seemed to dissuade the editors at Computers and Mathematics with Applications from publishing this one-page gem entitled "A computer application in mathematics" by the perhaps fictitious M. Sivasubramanian and S. Kalimuthu, the one working for Budweiser. It was published in January 2010 but not retracted until April 2012, despite silly sentences such as "Computer magnification is a Universal computer phenomenon" and "This is a problematic problem."

Two of the paper's references are to earlier, similar papers from M. Sivasubramanian, which also somehow got published. One is to a store that sells math games. And the other three are to non-existent websites. [5 Seriously Mind-Boggling Math Problems]

The journal, part of the respected Elsevier family of scientific publications, finally retracted the paper because it "contains no scientific content." The editors chalked it up to "an administrative error."

No pain, no gain?

stress, arguments, fights

(Image credit: Stressed Couple Image via Shutterstock)

Have you ever wondered whether there is any truth in the saying "no pain, no gain" or whether failure can be better for you than success?

The Dutch social psychologist Diederik Stapel has pondered such deep questions. His research has found that, paradoxically: failure sometimes feels better than success; beauty ads make women feel ugly; power increases infidelity among men and women; and comparing yourself to others might help you persevere with studying or dieting but ultimately won't make you happier.

Yes, Stapel has found lots and lots of stuff. His work has appeared in top journals. And his good looks and clever research topics made him a media darling, featured in The New York Times and on liberal-leaning television news programs.

The only problem is that his research appears to be either mostly or completely fabricated. So far, 31 papers have been retracted, according to Retraction Watch.

Rabbit testicles safe, for now

hugh heffner, lower marsh keys rabit, hugh's rabbit,

Lower marsh key rabbit, named Sylvilagus palustris hefneri after Hugh Heffner.
(Image credit: Wikimedia commons user Tomfriedel)

Studies proposing a link between cellphone use and cancer often rely on weak statistics. This one just used fudged data.

Back in 2008, scientists published a paper in the International Journal of Andrology stating that cellphones in standby mode lowered the sperm count and caused other adverse changes in the testicles of rabbits. [7 Surprising Facts About Sperm]

The study, although small and published in a rather obscure journal, made the news rounds. And the cautious human male, upon reading of the risks, might have moved his cellphone from his front pocket to the back.

In March 2012, the authors retracted the paper. It seems the lead author didn't get permission from his two co-authors and, according to the retraction notice, there was a "lack of evidence to justify the accuracy of the data presented in the article."

Stem-cell cure for heart disease likely faked

A fusion of several stem cells, called a myotube, obtained in vitro from a human muscle collected 17 days after the individual's death. The colored markers authenticate that they are muscle cells.

A fusion of several stem cells, called a myotube, obtained in vitro from a human muscle collected 17 days after the individual's death. The colored markers authenticate that they are muscle cells.
(Image credit: Fabrice Chretien)

The timing was perfect. Kyoto University biologist Shinya Yamanaka had just won the 2012 Nobel Prize for his discovery of induced pluripotent stem cells (iPS cells), which are adult cells that can be reprogrammed to their "embryonic" stage.

That's when Hisashi Moriguchi, a visiting researcher at the University of Tokyo, claimed at a New York Stem Cell Foundation meeting in early October to have advanced this technology to cure a person with terminal heart failure. It made sense, and the announcement rang around the world.

Just as quickly, however, the claim began to unravel. Two institutions listed as collaborating on Moriguchi's related papers — Harvard Medical School and Massachusetts General Hospital — denied that any of Moriguchi's procedures took place there. By Oct. 19, the University of Tokyo fired Moriguchi for scientific dishonesty even as the investigation was just getting underway.