Belly fat has long been thought to be particularly bad for your heart, but now, a new study adds more evidence to the idea that it may also be bad for your brain.
The study, from the United Kingdom, found that people who were obese and had a high waist-to-hip ratio (a measure of belly fat) had slightly lower brain volumes, on average, compared with people who were a healthy weight. Specifically, belly fat was linked with lower volumes of gray matter, the brain tissue that contains nerve cells.
"Our research looked at a large group of people and found obesity, specifically around the middle, may be linked with brain shrinkage,” lead study author Mark Hamer, a professor at Loughborough University’s School of Sport, Exercise and Health Sciences in Leicestershire, England, said in a statement.
The new findings, published today (Jan. 9) in the journal Neurology, suggest that the combination of obesity (as measured by body mass index, or BMI) and a high waist-to-hip ratio may be a risk factor for brain shrinkage, the researchers said.
However, the study found only an association between belly fat and lower brain volume, and cannot prove that carrying more fat around the waist actually causes brain shrinkage. It could be that people with lower volumes of gray matter in certain brain areas are at a higher risk of obesity. Future studies are needed to tease out the reasons for the link.
Belly fat, also called visceral fat, is fat that’s stored deep within the abdominal cavity. It’s tied to greater health risks than subcutaneous fat, or fat that’s stored just under the skin. Previous studies have linked visceral fat with a higher risk of heart disease (including heart attack and stroke), Type 2 diabetes, high blood pressure and premature death, according to the Mayo Clinic.
Some previous studies have also found a link between visceral fat or a high waist-to-hip ratio and lower brain volume, but these studies tended to be small and did not look at the combined effect of BMI and waist-to-hip ratio.
In the new study, the researchers analyzed information from more than 9,600 people living in the United Kingdom, with an average age of 55. Participants had their BMI and waist-to-hip ratio measured, and underwent an MRI to determine their brain volumes.
The study found that people with both a high BMI and high waist-to-hip ratio had the lowest brain volumes, compared with people who had just a high BMI (but not a high waist-to-hip ratio) and people of a healthy weight.
Specifically, people with both a high BMI and high waist-to-hip ratio had an average gray matter volume of 786 cubic centimeters, compared with 793 cubic centimeters for people with a high BMI but not a high waist-to-hip ratio; and 798 cubic centimeters for people of a healthy weight.
The findings held even after researchers took into account other factors that can affect brain volume, including age, smoking and high blood pressure.
Though the study didn't look at potential mechanisms linking visceral fat and brain shrinkage, one hypothesis is that this type of fat is thought to produce inflammatory substances that may play a role in brain atrophy, the researchers said.
Dr. Gayatri Devi, a neurologist at Lenox Hill Hospital in New York, who was not involved with the study, agreed with the findings. "Brain gray matter shrinkage...seems to be associated with obesity and with increased visceral fat,” she said.
"All this goes to show that good general health is very important for good brain health," Devi told Live Science.
A limitation of the study is that people who agreed to take part in the study tended to be healthier than people who did not want to take part, so the results may not apply to the general population as a whole, the researchers noted.
- Ten Things You Didn't Know About Fat
- 13 Kitchen Changes That Can Help You Lose Weight
- 10 Things We Learned About the Brain in 2018
Originally published on Live Science.
Live Science newsletter
Stay up to date on the latest science news by signing up for our Essentials newsletter.
Rachael is a Live Science contributor, and was a former channel editor and senior writer for Live Science between 2010 and 2022. She has a master's degree in journalism from New York University's Science, Health and Environmental Reporting Program. She also holds a B.S. in molecular biology and an M.S. in biology from the University of California, San Diego. Her work has appeared in Scienceline, The Washington Post and Scientific American.