Humans Might Sense Oxygen Through Skin

A breathtaking trick potentially left over from our amphibian ancestors might be found in us — the ability to sense oxygen through our skin.

Amphibians have long been known to be capable of breathing through their slimy hides. In fact, the first known lungless frog that breathes only through its skin was discovered recently in the rivers of Borneo.

Now the same oxygen sensors found in frog skins and in mammalian lungs have unexpectedly been discovered in the skin of mice.

"No one had ever looked," explained researcher Randall Johnson, a molecular biologist at the University of California, San Diego.

Mice and frogs are quite distant relatives, separated by more than 350 million years of evolution, so the fact they have these molecules in common in their skin suggests these compounds might well be found in the skin of other mammals also, such as humans.

"We have no reason to think that they are not in the skin of people too," Johnson said.

The discovery could lead to ways to boost oxygen levels in the blood of athletes in peak health and also people in bad health.

These molecules not only detect oxygen, but one of the compounds the researchers investigated helps ramp up levels of vital red blood cells, which ferry oxygen around the body.

When oxygen is limited, the body hikes up red blood cell production by pumping out the hormone erythropoietin, or "epo." Normal mice breathing in air that is 10 percent oxygen — a dangerously low level akin to conditions at the top of Mount Everest, and roughly half that of air at sea level — boost epo levels up 30-fold. However, mice that had the oxygen sensor HIF-1a genetically removed from their skin failed to produce this hormone even after hours of such low oxygen.

These findings, if they hold true in humans, suggest one could jack up the level of oxygen circulating inside the body simply by manipulating the skin and boosting red blood cell levels. This could help treat lung diseases and disorders such as anemia without injecting drugs that mimic epo, which make up a multibillion-dollar market, Johnson said.

Elite athletes also often try ramping up how much oxygen gets delivered to their muscles in order to improve their performance. They often do this by training at high altitudes or in low-oxygen tents. The new study suggests they might want to expose their skin as well as breathing in low-oxygen air to enhance their performance. "It's hard to say what exactly might be done, however — there's a lot we don't know yet," Johnson explained.

One important future goal for scientists is to investigate different kinds of mammals for this response. "Clearly, aquatic mammals would differ greatly in how their skin adapts to oxygen, and in all likelihood high altitude animals from those adapted to life at sea level," Johnson said.

The scientists detailed their findings in the April 18 issue of the journal Cell.

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