The coronavirus that started in Wuhan has sickened more than 4,000 people and killed at least 100 in China as of Jan. 27. Thailand and Hong Kong each have reported eight confirmed cases, and five people in the U.S. have been diagnosed with the illness. People are hoping for a vaccine to slow the spread of the disease.
Is there a vaccine under development for the coronavirus?
Was work underway on this particular strain?How do scientists know when to work on a vaccine for a coronavirus?What does this work involve, and when might we actually have a vaccine?Can humans ever be safe from these types of outbreaks?
Scientists are just getting started working, but their vaccine development strategy will benefit both from work that has been done on closely related viruses, such as SARS and MERS, as well as advances that have been made in vaccine technologies, such as nucleic acid vaccines, which are DNA- and RNA-based vaccines that produce the vaccine antigen in your own body.
Was work underway on this particular strain?
No, but work was ongoing for other closely related coronaviruses that have caused severe disease in humans, namely MERS and SARS. Scientists had not been concerned about this particular strain, as we did not know that it existed and could cause disease in humans until it started causing this outbreak.
How do scientists know when to work on a vaccine for a coronavirus?
Work on vaccines for severe coronaviruses has historically begun once the viruses start infecting humans.
Given that this is the third major outbreak of a new coronavirus that we have had in the past two decades and also given the severity of disease caused by these viruses, we should consider investing in the development of a vaccine that would be broadly protective against these viruses.
What does this work involve, and when might we actually have a vaccine?
This work involves designing the vaccine constructs – for example, producing the right target antigens, viral proteins that are targeted by the immune system, followed by testing in animal models to show that they are protective and safe.
Once safety and efficacy are established, vaccines can advance into clinical trials in humans. If the vaccines induce the expected immune response and protection and are found safe, they can be mass produced for vaccination of the population.
Currently, we lack virus isolates – or samples of the virus – to test the vaccines against. We also lack antibodies to make sure the vaccine is in good shape. We need the virus in order to test if the immune response induced by the vaccine works. Also, we need to establish what animals to test the vaccine on. That potentially could include mice and nonhuman primates.
Vaccine development will likely take months.
Can humans ever be safe from these types of outbreaks?
We expect that these types of outbreaks will occur for the foreseeable future in irregular intervals.
To try to prevent large outbreaks and pandemics, we need to improve surveillance in both humans and animals worldwide as well as invest in risk assessment, allowing scientists to evaluate the potential threat to human health from the virus, for detected viruses.
We believe that global action is needed to invest in novel vaccine approaches that can be employed quickly whenever a new virus like the current coronavirus – and also viruses similar to Zika, Ebola or influenza – emerges. Currently, responses to emerging pathogens are mostly reactive, meaning they start after the outbreak happens. We need a more proactive approach supported by continuous funding.
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Aubree Gordon is a professor of Public Health at the University of Michigan. Her research interests are the areas of infectious disease epidemiology and global health. Her current research focuses on the epidemiologic features and transmission of influenza in Nicaragua. In addition, Aubree collaborates on several ground-breaking studies on dengue, Zika, and chikungunya.
Um, the answer is clear. It usually takes up to 10 years to get a vaccine approved. That is way too much time and $$$ to be wasted on research and development.... welcome to the fast track, ladies and gentlemenReply
Yeah, although it doesn't take 10 yrs. It takes 3 months to create and about 1 year to get it approved.Reply
Lmnop said:Um, the answer is clear. It usually takes up to 10 years to get a vaccine approved. That is way too much time and $$$ to be wasted on research and development.... welcome to the fast track, ladies and gentlemen
Sorry doomsayers- there is already a vaccine for it. Russia made one. They also made a preventative vaccine for ebola as well as a cure medicine. Didn't know that did you? It's the Western media blackout on foreign news... So this whole story and all of its comments so far are pointless.Reply
How do you know this? What are you reading? Please share...thejames said:Sorry doomsayers- there is already a vaccine for it. Russia made one. They also made a preventative vaccine for ebola as well as a cure medicine. Didn't know that did you? It's the Western media blackout on foreign news... So this whole story and all of its comments so far are pointless.
Have not developed vaccine for the coronavirus yet?admin said:One of the dangers of the novel coronavirus is that there is no treatment -- and no vaccine. Researchers are working on one, but will it be in time to help with the current outbreak?
Coronavirus vaccine still months out. Here's why. : Read more
Can I suggest to extract antibodies from "hawk"to try if it is suitable for it?NHC said:Have not developed vaccine for the coronavirus yet?