Timothy Ray Brown, famous for being the first person to be cured of HIV, has died from cancer at age 54.
Known as the "Berlin patient," Brown was diagnosed with both HIV and acute myeloid leukemia, a cancer of the white blood cells, while living in Berlin more than a decade ago, according to Reuters. After his cancer diagnosis in 2006, Brown received radiation therapy and a bone marrow transplant in 2007; the goal of the treatment was to kill the existing cancer in his body and jumpstart production of healthy white blood cells, which are generated in the bone marrow.
But the physician who led the procedure, Dr. Gero Huetter, aimed to treat both Brown's leukemia and his HIV using the same operation, according to The Associated Press.
Huetter sought out a bone marrow donor with a rare genetic mutation that provides natural resistance against HIV infection. The virus normally targets white blood cells called CD4-T cells, which it infiltrates through a specific receptor on the cells' surfaces; people with the genetic mutation have an altered version of this receptor, so the virus can't slip inside, Live Science previously reported.
After his initial bone marrow transplant in 2007, Brown was cleared of HIV and remained free of the virus until his death, The Associated Press reported. He required a second transplant in 2008 to eliminate his leukemia, but after years in remission, the cancer returned last year and spread to his spine and brain, Reuters reported.
"I'm heartbroken that my hero is now gone. Tim was truly the sweetest person in the world," Brown's partner Tim Hoeffgen wrote in a Facebook post, according to Reuters.
"We owe Timothy and his doctor, Gero Huetter, a great deal of gratitude for opening the door for scientists to explore the concept that a cure for HIV is possible," Adeeba Kamarulzaman, president of the International AIDS Society, told Reuters.
Originally published on Live Science.