Do Brains Shrink As We Age?

Human brains are about three times as large as those of our early australopithecines ancestors that lived 4 million to 2 million years ago, and for years, scientists have wondered how our brains got so big. A new study suggests social competition could be behind the increase in brain size. CREDIT: NIH, NIDA

As we get older, our brains get smaller, or at least that's what many scientists believe. But a new study contradicts this assumption, concluding that when older brains are "healthy" there is little brain deterioration, and that only when people experience cognitive decline do their brains show significant signs of shrinking.

The results suggest that many previous studies may have overestimated how much our brains shrink as we age, possibly because they failed to exclude people who were starting to develop brain diseases, such as dementia, that would lead to brain decay, or atrophy.

"The main issue is that maybe healthy people do not have as much atrophy as we always thought they had," said Saartje Burgmans, the lead author of the study and a PhD candidate at Maastricht University in the Netherlands.

Burgmans and her colleagues wondered what would happen if they were able to screen out all of the people with so-called "preclinical" cognitive diseases. Using information collected for Holland's Maastricht Aging Study, the researchers analyzed data from 65 "healthy" individuals who did not show signs of dementia, Parkinson's disease or stroke and who were monitored for a period of nine years. Participants were on average 69 years old at the study's start.

Every three years, participants completed neuropsychological tests, which were designed to assess their cognition. They also underwent a brain MRI scan.

From the test results, the researchers divided the participants into two groups: a "healthy" group of 35 people, who showed no loss of mental abilities, and another group of 30 people who showed substantial cognitive decline, but did not have dementia.

Then, they analyzed the brain scans, looking at the size of seven regions associated with cognition. In the healthy group, age did not have a significant effect on brain size. In the other group, there was a large effect in all seven brain areas — older participants had significantly smaller brain areas than younger ones.

"What we found is that when you exclude all those people [who] are suspicious for preclinical disease, and you just look at the healthy people who don't have any suspicious cognitive decline, then you see that there is a very small age effect in this group," said Burgmans.

The researchers caution that their findings are only preliminary, and that they need to be confirmed in a larger group of people. Also, future studies should include brain scans of people over time, and not just one brain scan, as was the case for this study.

But their results demonstrate that it is important for scientists studying the aging brain to assess the cognition of their participants over a number of years, the researchers say.

The study was published in the September issue of the journal Neuropsychology.

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