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How a Zebrafish Regrows a Fin

Zebrafish (Danio rerio).
(Image: © Shawn Burgess, NHGRI)

If a zebrafish loses a chunk of its tail fin, not to worry, it'll grow the fin back within a week. How this fish along with other cold-blooded animals, such as lizards, newts and frogs, can replace complex body parts with the ease of magicians has eluded scientists.

Now a study has revealed some of the genes responsible for the cellular pathways that let a zebrafish restore its tail fin.

Veterinary and medical scientists wonder if warm-blooded animals that evolved from these simpler creatures, might still have untapped regenerative powers hidden in their genes.

Supporting this notion, a tail fin is made up of several different types of cells arranged into an intricate structure, making it the fish version of an arm or leg. The results of the new study, therefore, could help doctors craft treatments for people whose hearts, spinal cords, eyes or arms and legs have been injured.

They know that as a human embryo matures, loads of cells await the command that directs each to become a certain type of cell with a particular function such as a heart-muscle cell. Once tissue formation begins, a red-light signal puts the brakes on cell growth before it gets out of control.

Dubbed Wnt/Beta-catenin signaling, cell-to-cell conversations control the fate of these as-yet undeveloped cells in the embryo.

A team of scientists found this same signaling pathway also sparks the regeneration and subsequent growth of cells that make up tail fins in zebrafish. Another signaling pathway under the control of the so-called Wnt5b protein then turns down these genes, impairs cell growth and inhibits fin regeneration.

Fish with a mutant Wnt5b protein re-grow lost tails quickly. Too much of a related protein also boosts cell growth in the regenerating fin. "We can actually increase the rate of regeneration by turning on these genes," said study team member Randall Moon of the University of Washington.

The same genes for orchestrating this growth and development are found in humans, and drugs exist that can regulate this pathway. So, Moon added, the findings could be used in figuring out ways for humans to re-build damaged organs some day.

Also, interfering with the "off-switch" genes could promote tissue regeneration in mammals such as humans, the scientists suggest in the Dec. 21 online edition of the scientific journal Development.

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