The "miracle" of life meets cell biology in a mesmerizing 6-minute time lapse of a single cell dividing seemingly endlessly until what was once a yellow blob has become a wriggling, darting salamander tadpole.

"I wanted to film the origin of life," said Jan van IJken, a a photographer and filmmaker based in the Netherlands who created the recently released short, called "Becoming."

But what exactly is happening in this film? Live Science called a developmental biologist to learn more. [Photos: Bizarre Frogs, Lizards and Salamanders]

Van IJken was smart to choose an amphibious alpine newt. "You can look straight into the egg," he told Live Science. "They are transparent, and you can see the whole process." So, he contacted a salamander breeder and picked up a few dozen fertilized eggs.

But there are only a few hours between fertilization and the first cell division, so van IJken had to race home and, like a microsurgeon, unfurl and unglue each egg from the leaf where the salamander mother had carefully stuck it. "Sometimes, I was just in time," van IJken said.

Then, he placed the eggs in water-filled petri dishes and took thousands of photos using a camera attached to a microscope for the next four weeks.

In that initial shot, you can see the fertilized egg (also called an embryo) in the clear, protective vitelline membrane, said Lionel Christiaen, an associate professor of biology at New York University, who wasn't involved with the film. This membrane "helps keep the egg moist and prevents pathogens from getting in," Christiaen told Live Science.

In almost no time at all, the yellow salamander embryo has already divided into hundreds of cells.
In almost no time at all, the yellow salamander embryo has already divided into hundreds of cells.
Credit: Becoming, a film by Jan van IJken

Then, the embryo divides like a maniac. Rather than expanding in size, the embryo increases its number of cells with every division, all within in that same amount of space. There is a lag as each cell replicates the genetic material within it and then divides, in a process called mitosis, Christiaen said.

At about the minute mark in the film, a "hole" appears in the embryo. The process that creates the hole is called gastrulation, when the embryo organizes itself into three distinct cell layers. The importance of gastrulation was captured by Lewis Wolpert, a retired developmental biologist, who famously said, it's "not birth, marriage or death, but gastrulation which is truly the most important time in your life."

At the gastrulation stage, the embryo consists of thousands of cells, and some already "know" that they, or their progeny, will become brain cells, gut cells or something else. "But many of these cells are still on the outside of the egg," Christiaen said. During gastrulation, cells move around, organizing themselves by going to the outermost layer, or ectoderm (nervous system, skin cells and pigment cells); the mesoderm (gut, muscles and red blood cells); or the inner layer, or endoderm (lung cells, thyroid cells and pancreatic cells).

At about the 1:50 mark, the embryo looks like it's putting on a coat. This process is known as neurulation, Christiaen said, and it happens as the neural tube rolls up. After this step, almost everything on the outside of the embryo is there to stay. This consists mostly of the organism's protective skin. [In Photos: How Snake Embryos Grow a Phallus]

At about 3 minutes into the video, you can see the limb buds forming. Soon enough, you can distinguish the head from the tail. Van IJken stopped taking photos for the time lapse and switched to video as soon as the embryo moved, he noted.

Shortly after that, a tube that eventually becomes the heart begins to form, Christiaen said. And once the heart beats, blood flows. You can even see the blood flowing through the gills, the structures that help the animal with gas exchange so that it can breathe underwater.

The developing salamander twitches as it gets older, likely because its growing brain is learning how to control the animal's muscles, Christiaen said.

Finally, the yellow tadpole breaks free from the protective membrane. It's unclear how the animal knows when to do this, but hormones could play a role, Christiaen said. "There's no satisfying answer" to that question, he said.

Watching the tadpoles hatch "was incredible" van IJken said. "How this internal clockwork makes the whole thing come to life, it's incredible. It's a true miracle, one cell dividing and then becoming this animal."

And the circle of life continues, he noted. After the tadpoles hatched, van IJken gave them back to the breeder and got to work editing the film.

Editor's note: You can also see "Becoming" on Jan van IJken's Vimeo page.

Originally published on Live Science.