Scientists discover new organ in the throat

a new set of salivary glands has been found hiding behind the nose
(Image credit: The Netherlands Cancer Institute)

Scientists have discovered a new organ: a set of salivary glands set deep in the upper part of the throat. 

This nasopharynx region — behind the nose — was not thought to host anything but microscopic, diffuse, salivary glands; but the newly discovered set are about 1.5 inches (3.9 centimeters) in length on average. Because of their location over a piece of cartilage called the torus tubarius, the discoverers of these new glands have dubbed them the tubarial salivary glands. The glands probably lubricate and moisten the upper throat behind the nose and mouth, the researchers wrote online Sept. 23 in the journal Radiotherapy and Oncology.

The discovery was accidental. Researchers at the Netherlands Cancer Institute were using a combination of CT scans and positron emission tomography (PET) scans called PSMA PET-CT to study prostate cancer. In PSMA PET-CT scanning, doctors inject a radioactive "tracer" into the patient. This tracer binds well to the protein PSMA, which is elevated in prostate cancer cells. Clinical trials have found that PSMA PET-CT scanning is better than conventional imaging at detecting metastasized prostate cancer.

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PSMA PET-CT scanning also happens to be very good at detecting salivary gland tissue, which is also high in PSMA. Until now, there were three known large salivary glands in humans: one under the tongue, one under the jaw and one at the back of the jaw, behind the cheek. Beyond those, perhaps a thousand microscopic salivary glands are scattered throughout the mucosal tissue of the throat and mouth, study co-author and Netherlands Cancer Institute radiation oncologist Wouter Vogel said in a statement.

"So, imagine our surprise when we found these," Vogel said. 

To confirm the discovery, Vogel and his colleagues imaged 100 patients (99 of them men due to the focus on prostate cancer) and found that all of them had the newly discovered glands. They also dissected that nasopharynx region from two cadavers from a human body donation program and found that the newfound region consisted of mucosal gland tissue and ducts draining into the nasopharynx. 

The discovery could be important for cancer treatment. Doctors using radiation on the head and neck to treat cancer try to avoid irradiating the salivary glands, Vogel said, because damage to these glands can impact quality of life. 

"Patients may have trouble eating, swallowing or speaking, which can be a real burden," he said. 

But because no one knew about the tubarial salivary glands, no one tried to avoid radiation in that region. The researchers examined records from more than 700 cancer patients treated at the University Medical Center Groningen and found that the more radiation the patients had received in the area of the unknown glands, the more side effects they reported from their treatment. The new discovery could thus translate to fewer side effects for cancer patients.

"Our next step is to find out how we can best spare these new glands and in which patients," Vogel said. "If we can do this, patients may experience less side effects, which will benefit their overall quality of life after treatment."

Originally published on Live Science.

Stephanie Pappas
Live Science Contributor

Stephanie Pappas is a contributing writer for Live Science, covering topics ranging from geoscience to archaeology to the human brain and behavior. She was previously a senior writer for Live Science but is now a freelancer based in Denver, Colorado, and regularly contributes to Scientific American and The Monitor, the monthly magazine of the American Psychological Association. Stephanie received a bachelor's degree in psychology from the University of South Carolina and a graduate certificate in science communication from the University of California, Santa Cruz. 

  • jcwillia1
    fascinating. I've been struggling with a chronic dry, sore throat on and off for most of my adult life. I wonder if these glands are to blame.
  • Lee Harrison
    And I've been struggling with a chronic, post nasal drip-type cough most of my life! (These days, I can clear a grocery store is a split second!) I'm blaming the new glands!
  • Ilikesince
    hope you to get better soon!
  • jessbar1
    Serious question: Do you all know when someone says omg that tastes like soap! And someone else is like well how do you know what soap taste like, and you can't explain it but when you smell things you can almost taste them.... well can this be the reason why that happens? Considering the saliva glands is behind our nose !
  • RickK
    For the past two years I have been suffering from pain in my naso-pharyngeal area. It is not constant but can come on suddenly and last for many hours with varying degrees of pain. It also feels like my lower jaw is being constantly pulled down and off my face.
    IF you are a SCUBA diver, I have described this feeling to many doctors as having done several dives with much up and down in the water column where I would be constantly clearing my ears. My eustachian tubes at the point of entry to my pharynx feel raw... and can and do get very painful.
    Some days I can do no more than lie on the couch all day.
    The pain only goes away when I am completely relaxed. Like ASLEEP! When I wake in the morning I generally have no pain and can continue to lie in bed with little or no pain. After 15 mins or so of being up, the pain with begin. First it is just annoying. That can be for several hours. But then it will get more painful such that I have to take analgesics to alleviate it.
    I have had Xrays, CT scans, nasal camera probes, blood tests, MRIs ... nothing has been determined.

    Perhaps. Just perhaps. This new found gland has something to do with my condition.

    I have had dozens of well meaning "diagnoses" from so many people. No one has come up with anything.
    Anyone that MIGHT have a lead for something... I would appreciate it.