Rare diseases — Medical conditions you may never have heard of before

Patients with PFIC develop liver failure as a result of a buildup of a digestive fluid known as bile.

Most people are exposed to the fungi that cause mucormycosis regularly, but in certain individuals, these microbes can cause a potentially deadly infection.

Only around 500 cases of Norrie disease, a genetic condition, have been reported worldwide.

LIG4 syndrome is an exceptionally rare disorder caused by a genetic mutation that prevents the body from repairing damaged DNA.

Alkaptonuria is an unusual disorder caused by a defect in protein metabolism.

Capnocytophaga infections in humans are rare, especially in historically healthy individuals, but when it occurs, the disease can be deadly.

Argyria is caused by a buildup of silver in the body, which discolors the skin.

Tularemia, or "rabbit fever," is an infectious disease that normally affects animals but can spread to humans, sometimes via tick and deer fly bites.

Situs inversus is a rare genetic condition that causes the organs in the chest and abdomen to be located on the opposite side from where they're usually found, like a mirror image.

Frosted branch angiitis is a rare condition that makes the blood vessels that supply the retina look like the frosted branches of a tree.