Moms' Bacteria May Affect Brain Development in Baby Mice

The microbiota in mother mice is passed on to their babies, where it may affect brain development. (Image credit: RIKEN)

SAN DIEGO — Mothers pass on more than just love to their babies: As infants pass through the birth canal, they also get a healthy dose of mom's bacteria.

Now, research shows that mother mice that experienced stress before giving birth exhibited changes in the bacteria of their vaginas, affecting the microbes they passed on to their offspring. The range of bacteria, or microbiome, that young mice are exposed to influences their brain development, the researchers said.

In the new study, the researchers exposed pregnant mice to a range of stressors before the mice gave birth. For example, the researchers exposed the mice to the scent of a predator, or put marbles in their cage overnight, which "freaks the mice out," said study researcher Tracy Bale, a neuropharmacologist at the University of Pennsylvania. [5 Ways Gut Bacteria Affect Your Health ]

For comparison, another group of pregnant females was not exposed to the stress. After all of the mice gave birth, the scientists genetically sequenced the bacteria in the mothers' vaginas and the offspring's guts.

The researchers found that the stressed mothers had lower levels of a bacterium called Lactobacillus — which is found in probiotics, and is generally considered to be beneficial — in their vaginas after giving birth. Furthermore, the stressed mothers' offspring had similarly lowered amounts of Lactobacillus bacteria in their guts.

"Lactobacillus has been shown to be related to all kinds of processes in the gut related to brain development," Bale told LiveScience.

Bale and her colleagues also measured the offspring mice's blood levels of molecules that are building blocks for important brain chemicals, including histidine, a precursor to the critical brain signaling chemical histamine.

The offspring of stressed mothers had lower levels of histidine and other vital brain molecules compared with the offspring of unstressed mothers. The findings suggest that stressed mothers may bequeath less of the good bacteria that offspring need to develop healthy brains, the researchers said, though they noted their findings have not yet been published in a scientific journal.

In previous mouse studies, Bale and her colleagues showed that stressed mother mice give birth to offspring that display psychiatric problems.

However, the findings seem to apply only to male offspring, Bale noted, explaining that this may have something to do with the difference in genes expressed by males and females.

"It's some of the coolest stuff I've seen," said Jeffrey Blaustein of the University of Massachusetts, Amherst, who was not involved in the research. "A lot of us are thinking about how the vaginal microbiome might influence the brain, and they've already started on it," Blaustein, who is the former editor-in-chief of the journal Endocrinology, told LiveScience.

In people, some research suggests that babies born by Caesarian section may be missing out on a healthy dose of their mother's vaginal bacteria. If Bale's finding is also true of humans, it would suggest that maternal stress could have important consequences for early infant brain development.

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Tanya Lewis
Staff Writer
Tanya was a staff writer for Live Science from 2013 to 2015, covering a wide array of topics, ranging from neuroscience to robotics to strange/cute animals. She received a graduate certificate in science communication from the University of California, Santa Cruz, and a bachelor of science in biomedical engineering from Brown University. She has previously written for Science News, Wired, The Santa Cruz Sentinel, the radio show Big Picture Science and other places. Tanya has lived on a tropical island, witnessed volcanic eruptions and flown in zero gravity (without losing her lunch!). To find out what her latest project is, you can visit her website.