Worm Regeneration May Lend A Hand in Human Healing

planarians, worms, cell regeneration, stem cells, genes — Flatworms’ stem cells (in color, left image) and excretory organs (pink clusters, right image) could provide insight into our own—and pave the way toward regenerative therapies. (Image credit: Peter Reddien, Whitehead Institute for Medical Research (left); Jochen Rink, Max Planck Institute, and Hanh Thi-Kim Vu, Stowers Institute for Medical Research (right))

This Research in Action article was provided to LiveScience in partnership with the National Science Foundation.

About the size of toenail clippings, planarians are freshwater flatworms that can re-form from tiny slivers. This feature not only lets them repair themselves, but it lets them reproduce by breaking apart and then creating new worms.

Here are two other important features: More than half of planarian genes have parallels in people, and some of their basic physiological systems operate like ours. By studying how these features behave as the worms regenerate, scientists might move one step closer to learning how to generate or regenerate human tissue and cells, such as insulin-producing cells for people with diabetes or nerve cells for patients with spinal cord injuries.

The picture on the left shows a cell colony grown from a single planarian stem cell, which, like a human embryonic stem cell, has the potential to become many different cell types. Here, the cells labeled red will create more stem cells like themselves, and the cells labeled blue will make functional flatworm tissue like muscle and skin. Scientists at the Whitehead Institute for Biomedical Research inhibited certain planarian genes and then studied how the colonies changed.

The researchers were able to quantify the results, and, from what they learned, implicate the genes responsible for cell renewal and those spurring the creation of different cell types. They hope to use this knowledge to pinpoint parallels in mammals, perhaps one day harnessing the regenerative power of human embryonic stem cells.

The other image shows a cross-section of a flatworm. The green clusters and magenta specks throughout the planarian are specialized structures that push waste toward the animal’s bile ducts. These organs, which comprise the animal’s excretory system, are like our kidneys, in that the structures are lined with cells and the ducts employ comparable filtration methods. One key difference, though, is that flatworms can regenerate their excretory systems from next to nothing.

To better understand how this regeneration happens, researchers at the Stowers Institute for Medical Research removed the heads from planarians and watched as the creatures regrew the missing body part, including tubular structures of the excretory system. Among other findings, they learned that interfering with the expression of one gene kept the tubules and pores from branching off a precursor structure and from re-forming. This suggests the gene plays a critical role in regeneration. Studying similar genes in mammals could shed light on how we maintain our kidneys — and might grow new ones.

This research was supported by the National Institutes of Health. To see more images and videos of basic biomedical research in action, visit NIH's Biomedical Beat Cool Image Gallery.

Editor's Note: Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author and do not necessarily reflect the views of the National Science Foundation. See the Research in Action archive.

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