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Coronavirus may dice heart muscle fibers into tiny snippets, remove cells' DNA

When scientists mixed the new coronavirus with heart cells in a lab dish, the virus appeared to carve heart muscle fibers into small fragments. On the left, an image of healthy heart muscle cells, which have long fibers that allow them to contract. On the right, an image of heart muscle cells infected with SARS-CoV-2 in which the long fibers appeared to be diced into small pieces.
When scientists mixed the new coronavirus with heart cells in a lab dish, the virus appeared to carve heart muscle fibers into small fragments. On the left, an image of healthy heart muscle cells, which have long fibers that allow them to contract. On the right, an image of heart muscle cells infected with SARS-CoV-2 in which the long fibers appeared to be diced into small pieces.
(Image: © Gladstone Institutes)

The new coronavirus seems to slice heart muscle fibers into small, precisely sized fragments — at least when it infects heart cells in a lab dish, a new study reveals.

This snipping of muscle fibers, which could permanently damage heart cells, is scary enough in a lab dish; but the researchers found evidence that a similar process could be happening in the hearts of COVID-19 patients as well. However, the new finding, which was published to the preprint database bioRXiv on Aug. 25, has not yet been published in a peer-reviewed journal, or proven to happen in people.

The finding is unlike anything researchers have seen before — no other disease is known to affect heart cells in this way. "What we were seeing was completely abnormal," study co-author Todd McDevitt, a senior investigator at Gladstone Institutes, a nonprofit research organization in San Francisco, said in a statement

The new finding may explain how COVID-19 inflicts damage to the heart. Previous studies have found signs of heart abnormalities in COVID-19 patients, including inflammation of the heart muscle, even in relatively mild cases.

Related: Top 10 amazing facts about your heart 

For the new study, the researchers used special stem cells to create three types of heart cells, known as cardiomyocytes, cardiac fibroblasts and endothelial cells. In lab dishes, these cells were then exposed to SARS-CoV-2, the virus that causes COVID-19. Of the three types of cells, SARS-CoV-2 could infect and make copies of itself only inside cardiomyocytes, or heart muscle cells.

Cardiomyocytes contain muscle fibers that are made up of units called sarcomeres, which are critical to the muscle contractions that produce a heartbeat. These sarcomeres usually line up in the same direction to form long filaments. But the lab dish studies revealed something bizarre — the sarcomere filaments were chopped up into small fragments. 

"The sarcomere disruptions we discovered [in lab dishes] would make it impossible for the heart muscle cells to beat properly," study co-author Dr. Bruce Conklin, also a senior investigator at Gladstone Institutes, said in the statement. 

But findings in lab dishes don't always translate to real life. So the researchers analyzed autopsy samples of heart tissue from three COVID-19 patients. They saw that the sarcomere filaments were disordered and rearranged — a pattern that was similar to, but not exactly the same as, what was seen in the lab dish experiments.

More studies are needed to see if the sarcomere changes seen in heart cells are permanent. The authors note that scientists need to perform a special process to see the sarcomeres, which isn't usually done, explaining why this finding in autopsies may have been overlooked until now.

"I hope our work motivates doctors to review their patients' samples to start looking for these features," McDevitt said.

The researchers also observed another strange finding in both the lab dish experiments and the heart tissue from COVID-19 patients. They saw that, for some heart cells, the DNA inside the cells' nucleus seemed to be missing. This would render these cells essentially "brain dead" and unable to perform normal functions, the authors said.

Once scientists understand how SARS-CoV-2 damages heart cells, they could screen for drugs to mitigate these effects. For example, if the virus uses an enzyme to chop up sarcomeres, it may be possible to find a drug that blocks this enzyme. (However, the authors note that it's still unclear whether the virus directly cuts the sarcomeres, or if the virus triggers cells to cut the fibers through another mechanism.) 

"It will be important to identify a protective therapy, one that safeguards the heart from the damage we're seeing in our models," McDevitt said. "Even if you can't prevent the virus from infecting cells, you could put a patient on a drug to prevent these negative consequences from occurring while the disease is present."

Originally published on Live Science.  

  • Valentine Michael Smith
    I wonder why it would do such a thing, which might lead to answering why the difference in affect between lab and body.
    Reply
  • Christi B
    The differences in lab and body testing is that lab has separated out a single or selected cells/tissues to observe a single reaction or function which in its natural state would be affected by other chemicals, hormones, body responses or outside influences. such as - heart tissue damage could result in chemicals or toxins that trigger white cell or T-cell response to interfere with virus processes or encapsulate affected area - these responses are triggered in areas away from observed cells. Lab tests are investigative to narrow down areas of research, giving hints of what may be happening. Thats why medications don't have same results in everyone - different metabolisms, allergic reactions, hormonal responses, chemical/nutritional availability, etc. Hope that helps. Most things takes years of research to figure out how it all works together
    Reply