Cell Division Reversed in Possible Path to Cancer Treatment

One key to advanced life is cell division. Cells divide millions of times every day to sustain the life and growth of a single human.

But out-of-control cell division can fuel cancer.

Now scientists have for the first time reversed the process of cell division, a breakthrough that could eventually lead to treatments for cancer and other disorders.

They gained control over a protein responsible for division, then halted and reversed the process. Duplicate chromosomes were sent back to the center of the original cell, an event once thought impossible.

"Our studies indicate that the factors pointing cells toward division can be turned and even reversed," said lead researcher Gary Gorbsky of the Oklahoma Medical Research Foundation. "If we wait too long, however, it doesn't work, so we know that there are multiple regulators in the cell division cycle. Now we will begin to study the triggers that set these events in motion."

The research is detailed in the April 13 issue of the journal Nature.

"No one has gotten the cell cycle to go backwards before now," Gorbsky said. "This shows that certain events in the cell cycle that have long been assumed irreversible may, in fact, be reversible."

"Dr. Gorbsky's results provide elegant proof that the cell cycle must be precisely controlled," said Rodger McEver, vice president of research at the facility. "Now he and his lab can work toward developing innovative methods to probe and better understand the complex process of cell division.